Endocrine Abstracts

Background: Several cytokines and chemokines are released by adipose tissue and associated with insulin resistance. We investigated the systemic and in vitro release of RANTES(Regulated upon Activation Normal T-cell Expressed and Secreted), MCP-1(Monocyte Chemo-attractant Protein-1), adiponectin, leptin and IL-6 from three human adipose tissue depots and their relationship to insulin sensitivity.Methods: Fasting blood samples were taken from obese...

Background & aims: Data comparing the effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on type-2 diabetes (T2D) outcomes and the relationship between weight-loss (WL) and T2D remission are limited. Thus, we undertook a retrospective study of patients with obesity and T2D who underwent RYGB or SG and examined the relationship between 2-year (2y) post-surgery T2D and WL outcomes.Material & methods: Patients who underwent RYGB (...

Background: The number of women seeking bariatric surgery in order to improve their fertility is increasing. Current guidelines recommend that pregnancy should be delayed for at least 1 year post-surgery. However, there are limited data regarding pregnancy outcomes post-surgery, particularly for sleeve gastrectomy.Methods: We performed a single-centre, retrospective cohort study of pregnancies in women post-bariatric surgery. Surgical and maternity recor...